grepninjalog: GrepNinja's Weblog
GrepNinja's weblog is a somewhat ordered collection of thoughts and resources mostly related to software engineering. It simply tracks what GrepNinja finds technologically useful, interesting, or amusing at some given point in time.

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Monday, September 17, 2001
Wiki for Camp Smalltalk @ OOPSLA 2001

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Devguru.com: Beyond the Basics with SQL

DevGuru Jet SQL Quick Reference guide

Reminder: Schemers.org

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Data, Text and Web Mining (Kdnuggets.com)

DIMACS Working Group on Streaming Data Analysis and Mining I

Bayesian Statistics Personal Web Pages

Visual Molecular Dynamics (VMD) "is a molecular visualization program for displaying, animating, and analyzing large biomolecular systems using 3-D graphics and built-in scripting. VMD supports computers running MacOS-X, Unix, or Windows, is distributed free of charge, and includes source code."

Genome Sequencing Center (GSC) at the Washington University in St. Louis

The Sanger Centre "is a genome research centre founded by the Wellcome Trust and the Medical Research Council. Our purpose is to further the knowledge of genomes, particularly through large scale sequencing and analysis."

Wise2: "intelligent algorithms for DNA searches."

HMMER 2.2 -- Profile hidden Markov models for biological sequence analysis. Now contains full support for the latest Pfam annotations.

Pfam: Protein families database of alignments and HMMs

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Merck & Co., Inc.

GlaxoSmithKline

Maybridge Chemicals

Asinex

MDL Information Systems (MDL)

Useful QSAR Links

MedChem/Biobyte QSAR database

QSAR server at UNC Chapel Hill

Protein Explorer - requires Netscape, MSIE botches the required plugins.

Rasmol is a freeware software program for molecular visualization.

The successor to MidasPlus, a Molecular Display and Simulation System, is Chimera. an "extensible molecular modeling system."

Some Journals: Cell, Molecular Cell, and Developmental Cell

Article: New Method Permits Modeling Of Truly Large Molecules.

Here is a great science news resource: UniSci Daily University Science News.

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New article on SciTegic, Inc. and its data pipelining technology: " Ask More of Your Discovery Data"

An excellent article about SciTegic's data pipelining: " A river of data runs through it"

Tripos, Inc. -- drug discovery research software.

LION Bioscience Inc.

MDL Information Systems -- "discovery informatics for the life sciences and chemistry in industry and academia."

Google search for "high throughput molecular analysis"

Google search for "pharmacophore modeling"

Google search for "pharmacophore"

Google search for "computer aided drug design"

A good introductory summary: Richon, Allen B., "e; An Introduction to Molecular Modeling.

Here is a link to the Single Neucleotide Polymorphism (SNP) Database (dbSNP) at NCBI.

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Jacobe - The Java Pretty Printer is free but not Open Source.

Bio Informatics Technology & Systems (BITS) -- "BITSjournal explores new technologies and their impact in the life sciences. Applications for Bioinformatics, Genomics, Proteomics and Integrated Biology settings."

New in town: The R.W. Johnson Pharmaceutical Research Institute in La Jolla, CA.

Some links on cheminformatics:

IC#Code.net produces an Open Source development environment for .NET called SharpDevelop. Requires the .NET Beta 2 SDK.

Brinkster is an ASP.NET hosting service that provides both free and a paid "premium" access.

The XML UI Spec Builder was created for the Stable Squeak project, also known as the Squeak World Tour.

Ruby Style Guide

Follow the "yellow brick road" at the Smalltalk Webring.

A Smalltalk eZine: Smalltalk Chronicles

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Stanford University offers the Stanford Human Genome Center (SHGC) and the Stanford Genomic Resources

SanDiegoStartup.com

San Diego Regional Technology Alliance (SDRTA)

XML Mail Transport Protocol (XMTP) at The XML Cover Pages maps MIME/SMTP to XML.

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What If is "a versatile protein structure analysis program that can be used for mutant prediction, structure verification, molecular graphics, etc." This is a commercial product, so expect to PAY!

FlexX is "a computer program for predicting protein-ligand interactions." A free WWW interface is provided for public use.

Frontiers in Bioscience -- Meetings and Conferences.

The BCM Search Launcher at the Human Genome Sequencing Center (HGSC) of the Baylor College of Medicine organizes molecular biology-related search and analysis services under a single point of entry.

The WorldForge Project is developing massively multiplayer role playing game systems.

Some XML Parsers for Squeak

BioHunt - a "molecular biology finder" search engine.

The closest mirror site to the USA of the ExPASy Molecular Biology Server (Main site in Switzerland) is the Canadian ExPASy Mirror Site. ExPASy (Expert Protein Analysis System) is the proteomics server of the Swiss Institute of Bioinformatics (SIB).

SWISS-PROT is another major "curated protein sequence database."

GenBank -- see the Overview for basic information.

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Biocomputing for Everyone at VNS-BCD.

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Oh! Genetics Computer Group (GCG) was incorportated into Accelrys.

Unofficial Guide to GCG Software

FASTA3 at European Bioinformatics Institute (EMBL).

FASTA format description

PDB Format Description Version 2.2 (PDB = "Protein Data Bank").

Nodalpoint offers "Culture, molecular biology, biotechnology, linux and bioinformatics news for biogeeks."

The International Center for Cooperation in Bioinformatics network (ICCBnet) is a project under the auspices of UNESCO.

Bioinformatica.com claims to be "The ultimate hub for bioinformatics."

Lawrence Berkeley National Laboratory (LBNL), of the Department of Energy (DOE) also has a version of the DOE 2000 Electronic Notebook Project.

Computational Biology at ORNL: Analysis Tools

Environmental Molecular Sciences Laboratory (EMSL)

DOE 2000 Electronic Notebook Project

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HTScreening.net is a resource on high throughput screening and has a nice publications index.

UC Santa Cruz Human Genome Symposium 2001 will have a webcast available on Saturday, August 25, 2001, from 1 to 3:30 p.m.

The Protein Data Bank (PDB) is "the single worldwide repository for the processing and distribution of 3-D biological macromolecular structure data."

The BioMolecular Engineering Research Center offers many computational biology tools including the BMERC's PSA Server -- "The Protein Sequence Analysis (PSA) server predicts probable secondary structures and folding classes for a given amino acid sequence."

Protein Architecture and Function is section 5 of Concepts of Biochemistry, some course materials assembled as part of the Virtual Classroom at the Hardy Research Group, Department of Chemistry, The University of Akron.

What the PDB Teaches Us about Protein Architecture, a slide set.

Protein Architecture is an introductory lecture by Dr. R. A. Rastall, Ph.D. This lecture is part of his materials for Protein Structure and Function (fs916) at the University of Reading, in the UK.

Here is some information on a classic protein architecture text: Lesk, Arthur M., Introduction to Protein Architecture. A sample chapter is available.

Protein Architecture is a tutorial (with quiz) from the Molecular Models for Biochemistry at CMU site, which offers "...tutorials and quizzes that are based on Chime and RasMol images of the molecules and macromolecules found in biochemistry. They are intended to complement standard biochemistry texts where more explanation is provided, but where interactive 3-D images of the molecules are not available." Special viewers are required.

UNC Gamma Research Group -- Gamma = Geometric Algorithms for Modeling, Motion and Animation. One very significant project of this group is dAb, an interactive Haptic painting system that is very cutting edge.

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Highveld.com: the Internet Directory of Molecular Biology and Biotechnology and, specifically for GrepNinja's current purposes, Molecular Biology Protocols.

Cell and Molecular Biology Online

Article: Rubenstein, Ken Ph.D., " Pharmacogenomics - Impact on Drug Discovery"

Drug Discovery & Development

Drug Discovery and Development Glossary

Bioinformatics: Courses and Resources

VMware allows you to create multiple virtual machines on the same hardware. VMWare is a commercial product. Plex86, which used to be called FreeVMWare, is a similar Open Source project.

The Chemistry Preprint Server is "a permanent web archive and distribution medium for research articles in the field of chemistry. CPS allows users to submit their articles to the server where they become accessible to all the members of ChemWeb.com."

Squeak Foundation Swiki

Nature Biotechnology

BioMed Central

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Simple Smalltalk Testing: With Patterns, by Kent Beck.

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Genomics Glossary at Cambridge Healthtech Institute

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Project JANET will aim to provide "open implementation of ECMAScript (the standardized version of JavaScript) on the CLI platform."

Time to review the results: O'Reilly Open Source Convention Coverage.

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For Squeakers, here is Jim Benson's home page and project Zurgle.

The canonical list of Title Tags on the Squeak Email List has been recently revised.

Nant is a Sourceforge project to build an Ant-like build tool for .Net. Also, see NAnt - A .NET Build Tool.

.NET classes for Ant is a project to .NETify the Ant Java based build tools.

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Game Studies: Year One

SDL is the "Simple DirectMedia Layer," a cross-platform multimedia library with bindings to lots of languages.

An IBM-SMALLTALK centric Tutorial

For your daily dose of "retro," check out the FreeDos Project.

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IBM has made available a 50 page Technical FAQ for Linux Users in PDF format.

NCBI offers more genomics links on its Genomes Guide and The Human Genome pages.

Check out Ensembl, a joint project between EMBL - EBI and the Sanger Centre to develop a software system which produces and maintains automatic annotation on eukaryotic genomes.

Human Genome Central

The National Human Genome Research Institute hosts the Human Genome Project and has a great Researcher Resources section and more links at the Genome Hub.

Here is a little reminder about the Public Library of Science initiative.

Genomeweb

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The Tree of Life Project Root Page - biological taxonomy.

The NCBI BLAST site is a key bioinformatics resource. What is BLAST? The site describes it like this: "BLAST® (Basic Local Alignment Search Tool) is a set of similarity search programs designed to explore all of the available sequence databases regardless of whether the query is protein or DNA. "

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Introduction to Structured Query Language offers a basic SQL tutorial.

A mirror site for PostgreSQL, chosen from the main PostgreSQL.org site, has the full Release Documentation online.

SQL for Web Nerds by Philip Greenspun is an online book that covers SQL basics in a sometimes humorous way.

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Lutz Roeder's Programming .NET

Here is a Dave Winer piece on Miguel de Icaza's new efforts with the Mono Project at Ximian. Mono is getting some cooperation from Microsoft (see this FAQ). Here is a response from Miguel. Mono is "an effort to create a Free Software (sometimes called open source) implementation of the .NET Development Framework." These materials are a GrepNinja "Must Read."

One of my favorite groups of gurus has formed "The Agile Alliance" and has issued the Agile Manifesto. The group includes at least 17 key Extreme Programming (XP), Refactoring, and Pragmatic Programming people :
  • Kent Beck
  • Mike Beedle
  • Arie van Bennekum
  • Alistair Cockburn
  • Ward Cunningham
  • Martin Fowler
  • James Grenning
  • Jim Highsmith
  • Andrew Hunt
  • Ron Jeffries
  • Jon Kern
  • Brian Marick
  • Robert C. Martin
  • Steve Mellor
  • Ken Schwaber
  • Jeff Sutherland
  • Dave Thomas

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Open Directory Category for ISO 9000 information.

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Yea! BioRuby is now an active project. In addition, here are some other important Bioinformatics projects:

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Portable.NET - "The goal of this project is to build a suite of open source tools to build and execute .NET applications, including a C# compiler, assembler, disassembler, and runtime engine. The initial target platform is Linux, with other platforms to follow in the future."

Lincoln Stein wrote this fascinating article, " How Perl Saved the Human Genome Project" for The Perl Journal. It's a great introductory piece reproduced on the Bioperl.org site. Related projects are Biojava.org, Biopython.org, Bioxml.org, Biocorba.org. All can be reached from the Bioperl.org site.

Visual Parse++ is a next generation visual development environment for writing lexers and parsers.

The Prime Pages - everything you didn't realize you wanted to know about prime numbers.

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GNOME's Miguel de Icaza on .NET outlines efforts to make .NET available on UNIX and Linux systems. The new project is called Mono. O'Reilly has a new .NET Devcenter section.

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A reminder of the main site for the Whisker Browser, a cool Squeak Smalltalk goodie provided by Smalltalker Doug Way.

Squeak Fixes, Enhancements, Add-Ons - extracted from the Squeak email list.

A Newbie's On-going Tutorial is a new beginner's tutorial for Squeak Smalltalk.

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Linux Business Applications -- an interesting list.

Linux-elitists Email List

Another XML Starter page: xml.startkabel.nl/

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Google search: computational neurobiology

Google search: "computational neuroscience"

XML and Databases - Copyright 1999-2001 by Ronald Bourret

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